Author

Andrew R. Pepper

University of AlbertaORCID 0000-0002-2227-4446Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Physiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Erin E. MulvihilliD· 2 shared Haoning Howard CeniD· 2 shared James D. JohnsoniD· 2 shared Jennifer E. BruiniD· 2 shared Aaron Reyes· 1 shared Aliya F SpigelmaniD· 1 shared Andrew C. Clément· 1 shared Anna L. GloyniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPhysiology

Erin E. MulvihillORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Casp1 and Ripk3 are required for homeostatic insulin secretion in mice

Madison D. Girouard, Conor O’Dwyer, Cassandra A.A. Locatelli, Myriam P Hoyeck, Evgenia Fadzeyeva, Tyler K.T. Smith, Rui Yan Gao, Tanvi Ahluwalia, Sophia M. Perrakis, Andrew C. Clément, Antonio A. Hanson, Peyman Ghorbani, Lili Grieco-St-Pierre, Jianfan Nie, Mariam Hakoum, , Morgan D. Fullerton

This study shows that deleting both Casp1 and Ripk3 in mice improves glucose-stimulated insulin secretion, independent of cell death or inflammation.

bioRxiv · Sep 4, 2026 · PreprintPhysiology

Biological sex affects human islet gene expression and mitochondrial function in type 2 diabetes

Sing-Young Chen, Haoning Howard Cen, Charlotte F. Chao, Andrew R. Pepper, James D. Johnson, Elizabeth J. Rideout

This study examines sex differences in human islet gene expression and mitochondrial function in type 2 diabetes, finding female islets show greater preservation of insulin content and fewer functional defects.

Endocrinology · Mar 18, 2026Peer-reviewedCell Biology

HumanIslets: An integrated platform for human islet data access and analysis

Jessica Ewald, Yao Lu, Cara E. Ellis, Jessica Worton, Jelena Kolic, Shugo Sasaki, Dahai Zhang, Theodore dos Santos, Aliya F Spigelman, Austin Bautista, Xiao-Qing Dai, James G. Lyon, Nancy P. Smith, Jordan M. Wong, Varsha Rajesh, , Patrick E. MacDonald

HumanIslets.com provides an open platform for accessing and analyzing human islet data, enabling research on diabetes through integrated molecular and cellular phenotyping.

bioRxiv · Jun 19, 2024 · PreprintSystems Biology