Single-cell morphology encodes functional subtypes of senescence in aging human dermal fibroblasts
Pratik Kamat, Nicolas C. Macaluso, Yukang Li, Anshika Agrawal, Aaron Winston, Lauren Pan, Teasia Stewart, Bartholomew Starich, Nicholas Milcik, Chanhong Min, Pei-Hsun Wu, Jeremy D Walston, Jean Fan, Jude M. Phillip
This study identifies functional senescence subtypes in aging human dermal fibroblasts using single-cell morphology and machine learning, showing subtype-specific responses to senotherapies.
Science Advances · Apr 25, 2025Peer-reviewedBioengineering