Nicolas C. Macaluso

This study profiles Acomys cahirinus fibroblasts to show that Col3A1 expression and senescence-associated cell states influence matrix remodeling, contributing to scarless regeneration.

This study shows that monocyte behaviors can predict aging and frailty in humans using single-cell analysis and a deep learning model.

This study shows that increasing fluid viscosity can temporarily restore young-like surveillance behaviors in aged human T cells by improving deformability and sensing.

This study identifies functional senescence subtypes in aging human dermal fibroblasts using single-cell morphology and machine learning, showing subtype-specific responses to senotherapies.

This study shows that substrate stiffness affects the development and strength of senescence features in fibroblasts, with mechanosensitive regulation of key biomarkers.