Jeremy D Walston

Monocytes are biological sensors of aging and frailty in humans

This study shows that monocyte behaviors can predict aging and frailty in humans using single-cell analysis and a deep learning model.

Acute priming using elevated fluid viscosity recovers young-like single-cellsurveillance behaviors in aged human T cells

This study shows that increasing fluid viscosity can temporarily restore young-like surveillance behaviors in aged human T cells by improving deformability and sensing.

Single-cell morphology encodes functional subtypes of senescence in aging human dermal fibroblasts

This study identifies functional senescence subtypes in aging human dermal fibroblasts using single-cell morphology and machine learning, showing subtype-specific responses to senotherapies.

qMAP Enabled Microanatomical Mapping of Human Skin Aging

This study introduces qMAP, a deep learning-based workflow for microanatomical mapping of human skin, identifying 10 core processes strongly associated with aging and achieving age prediction accuracy comparable to epigenetic clocks.

Substrate stiffness modulates the emergence and magnitude of senescence phenotypes in dermal fibroblasts

This study shows that substrate stiffness affects the development and strength of senescence features in fibroblasts, with mechanosensitive regulation of key biomarkers.