Tau oligomers modulate synapse fate by eliciting progressive bipartite synapse dysregulation and synapse loss
Kristeen A. Pareja-Navarro, Christina D. King, Grant Kauwe, Yani Y. Ngwala, Doyle Lokitiyakul, Ivy Wong, Aaryan Vira, Yaofu Liu, Jackson H. Chen, Mahima Sharma, Gabriel Navarro, Olfat A. Malak, Chuankai Zhou, Birgit Schilling, Tara E. Tracy
This study shows that tau oligomers cause progressive synapse dysfunction by initially weakening both presynaptic and postsynaptic components, followed by synaptic loss.
Molecular Neurodegeneration · Jan 22, 2026Peer-reviewedNeuroscience