Grant Kauwe

Oral administration of dibenzoylmethane (DBM) prevents cognitive decline in a C9ORF72-mediated FTD mouse model

This study shows that oral DBM treatment prevents cognitive decline in a C9ORF72 FTD mouse model without altering protein inclusions but corrects gene expression changes related to cytoskeleton, ALS, and metabolism.

Tau oligomers modulate synapse fate by eliciting progressive bipartite synapse dysregulation and synapse loss

This study shows that tau oligomers cause progressive synapse dysfunction by initially weakening both presynaptic and postsynaptic components, followed by synaptic loss.

Pathogenic tau inhibits synaptic plasticity by blocking eIF4B-mediated local protein synthesis

KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss

This study shows that CT-KIBRA repairs synaptic plasticity and memory in tauopathy models by stabilizing PKMζ, without altering tau levels or preventing synapse loss.

A retrograde GCN2/eIF2α, but ATF4 independent, mechanism maintains synaptic strength under acute amino acid scarcity at the NMJ

The paper investigates how GCN2/eIF2α signaling maintains synaptic strength during acute amino acid scarcity at the Drosophila NMJ, showing ATF4 is dispensable and the pathway acts retrogradely from muscle to motoneuron.

Tau interactome mapping reveals dynamic processes in synapses and mitochondria associated with neurodegenerative disease

The paper maps Tau interactomes in neurons using APEX and AP-MS to reveal activity-dependent interactions and FTD mutation effects on mitochondrial associations in neurodegenerative diseases.