Author

Jackson H. Chen

Buck Institute for Research on Aging

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Assay:metagenomics· 1

Frequent Co-Authors

Grant Kauwe· 3 shared Kristeen A. Pareja-Navarro· 3 shared Tara E. TracyiD· 3 shared Alissa L. NanaiD· 2 shared Birgit SchillingiD· 2 shared Doyle Lokitiyakul· 2 shared Ivy WongiD· 2 shared Lea T. GrinbergiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Grant Kauwe

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Tau oligomers modulate synapse fate by eliciting progressive bipartite synapse dysregulation and synapse loss

Kristeen A. Pareja-Navarro, Christina D. King, Grant Kauwe, Yani Y. Ngwala, Doyle Lokitiyakul, Ivy Wong, Aaryan Vira, Yaofu Liu, Jackson H. Chen, Mahima Sharma, Gabriel Navarro, Olfat A. Malak, Chuankai Zhou, Birgit Schilling, Tara E. Tracy

This study shows that tau oligomers cause progressive synapse dysfunction by initially weakening both presynaptic and postsynaptic components, followed by synaptic loss.

Molecular Neurodegeneration · Jan 22, 2026Peer-reviewedNeuroscience

Pathogenic tau inhibits synaptic plasticity by blocking eIF4B-mediated local protein synthesis

Grant Kauwe, Doyle Lokitiyakul, Ivy L. Wong, Kevin Schneider, Varun Sridhar, Durai Sellegounder, Yani Y. Ngwala, Lei Yao, Jackson H. Chen, Kristeen A. Pareja-Navarro, Alissa L. Nana, Salvatore Spina, William W. Seeley, Lea T. Grinberg, Eric M. Verdin, , Tara E. Tracy

bioRxiv · Sep 11, 2025 · PreprintNeuroscience

KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss

Grant Kauwe, Kristeen A. Pareja-Navarro, Lei Yao, Jackson H. Chen, Ivy Wong, Rowan Saloner, Helen Cifuentes, Alissa L. Nana, Samah Shah, Yaqiao Li, David Le, Salvatore Spina, Lea T. Grinberg, William W. Seeley, Joel H. Kramer, , Tara E. Tracy

This study shows that CT-KIBRA repairs synaptic plasticity and memory in tauopathy models by stabilizing PKMζ, without altering tau levels or preventing synapse loss.

Journal of Clinical Investigation · Feb 1, 2024Peer-reviewedNeuroscience