MRCKα represses GEF-H1 mediated RhoA activation to promote ovarian cancer spheroid growth and invasion.
Aasiya Remtulla, Alison Kurimchak, Alicia Canuel, Ishadi K. M. Kodikara, Jason S. Wasserman, Alexandre Chuyen, Danielle Olding, Rajesh Gupta, Nikolina Radulovich, James S. Duncan, Michael F. Olson
This study identifies MRCKα as a repressor of GEF-H1-mediated RhoA activation, promoting ovarian cancer spheroid growth and invasion.
bioRxiv · Feb 9, 2026 · PreprintCell Biology