Mitochondrial Permeability Transition in Skeletal Muscle Phenocopies Muscle Alterations seen in Cancer Cachexia and other Wasting Conditions
Maya G. Semel, Cole J. Lukasiewicz, Sarah K. Skinner, Mark R. Viggars, Sung Gi Noh, Martin Picard, Abbey-Gale Mannings, Michael S. Cohen, Dennis W. Wolan, TERENCE EDWARD RYAN, Russell T. Hepple
This study shows that inducing mitochondrial permeability transition (mPT) in skeletal muscle mimics key features of cancer cachexia and other wasting conditions, suggesting mPT as a potential therapeutic target.
The Journal of Physiology · Sep 24, 2026Peer-reviewedPhysiology