Dennis W. Wolan

This study shows that inducing mitochondrial permeability transition (mPT) in skeletal muscle mimics key features of cancer cachexia and other wasting conditions, suggesting mPT as a potential therapeutic target.

This study shows that inhibiting SagA, a peptidoglycan hydrolase, increases vancomycin susceptibility in VREfm through both genetic and pharmacological approaches.

This study identifies isopentenyladenine as a secreted metabolite from Faecalibacterium prausnitzii that modulates host immune responses and mitigates gut inflammation in murine models.

The paper designs and characterizes non-hydrolyzable peptidomimetic inhibitors to selectively probe caspase-7 over caspase-3 by exploiting differences in their prime-side active-site architecture.

This study demonstrates that triflic acid treatment solubilizes insoluble bacterial biomass, enabling comprehensive proteomic analysis of Gram- and Gram+ bacteria and human microbiome samples.

The paper identifies the genetic basis for the cooperative bioactivation of plant lignans by a human gut bacterial consortium, revealing a complete metabolic pathway in most human gut microbiomes.

The paper uses metaproteomics to analyze colonic microbiota in colitic mice and controls, identifying changes in protein functions linked to inflammation.