Michael S. Cohen

This study shows that inducing mitochondrial permeability transition (mPT) in skeletal muscle mimics key features of cancer cachexia and other wasting conditions, suggesting mPT as a potential therapeutic target.

This study shows that PARP11-induced MARylation and ubiquitination of MHC-I in cancer cells promotes immunosuppression, tumor growth, and resistance to therapies.

The paper shows a population-specific PARP1 gene variant enhances the efficacy and toxicity of the PARPi drug talazoparib by altering its mechanism of action.

This study shows that PARP15's ADP-ribosyltransferase activity is regulated by dimerization, with dimers required for catalytic function and monomers inactive.

This paper shows PARP14 promotes IFN production and has both antiviral and proviral functions against multiple viruses.

The paper identifies RNF114 as an E3 ligase that extends K11 polyubiquitin on MARUbylated sites, revealing a novel mechanism of Ub-ADPr recognition and polyubiquitylation.

This paper discovers a new dual post-translational modification, MARUbylation, where PARP10 is mono-ADP-ribosylated and ubiquitylated on Glu/Asp residues, leading to proteasomal degradation.

This paper introduces a genetically encoded FRET probe (pARS) for real-time monitoring of PARylation dynamics in vitro and in live cells, showing its utility in detecting PARP1 activity and inhibitor potency.

This paper introduces a method to specifically label nascent proteins in Drosophila brain cells using PhAc-OPP and PGA, revealing age-related declines in neuronal protein synthesis.