TERENCE EDWARD RYAN

This study shows that inducing mitochondrial permeability transition (mPT) in skeletal muscle mimics key features of cancer cachexia and other wasting conditions, suggesting mPT as a potential therapeutic target.

This study shows that FAM210A deficiency in hepatocytes causes juvenile mitochondrial dysfunction and steatosis, which resolves in adulthood through compensatory mechanisms.

This study shows that ovarian failure or removal increases atherosclerosis but does not impair limb recovery in a mouse model of peripheral artery disease.

This study shows that intramuscular adipose tissue (IMAT) accumulation worsens limb function in PAD/CLTI, and reducing IMAT improves muscle strength and work output in mice.

This study shows that blocking intramuscular adipose tissue (IMAT) formation after muscle injury improves muscle regeneration and function in mice.

This paper develops a 6-minute limb function test for preclinical hindlimb ischemia models to assess muscular performance and hemodynamics, showing it detects therapeutic differences better than traditional measures.

The paper uses single nuclei RNA sequencing to analyze muscle from PAD patients and controls, identifying transcriptional changes and cell type alterations associated with the disease.