Spike-specific IgG4 generated post BNT162b2 mRNA vaccination is inhibitory when directly competing with functional IgG subclasses
Jerry C H Tam, Abbie C. Sibayan, Jeffrey Seow, Carl Graham, Ashwini Kurshan, Blair Merrick, Richard James Stanton, Katie J. Doores
This study shows that Spike-specific IgG4 generated after BNT162b2 vaccination can inhibit effector functions when competing with other IgG subclasses, despite overall increased neutralization and effector activity.
Cell Reports · Jul 1, 2025Peer-reviewedImmunology