Multiviral RBD-decorated chimpanzee adenoviral vaccine elicits broad neutralizing immunity against diverse betacoronaviruses
Bethany G. Charlton, Rosa D'Agostino, Rebecca A Russell…·Matthew D. J. Dicks
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King's College LondonORCID 0000-0003-0722-8561Unclaimed ORCID profile · follow to get notified of new preprints
7 papers
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Bethany G. Charlton, Rosa D'Agostino, Rebecca A Russell…·Matthew D. J. Dicks
Luke B. Snell, Suzanne Pickering, Adela Alcolea-Medina…·Rui Pedro Galão
The paper identifies diverse spike haplotypes in persistent SARS-CoV-2 infections that show immune escape mechanisms similar to variants of concern.
Ayush Upadhyay, Jeffrey Seow, Yilmaz Alguel…·Katie J. Doores
This study identifies cross-neutralizing mAbs against diverse bat sarbecoviruses and characterizes their conserved epitopes for vaccine design.
Nazia Thakur, Joseph Newman, Dongchun Ni…·Dalan Bailey
This study examines the host range and antigenicity of bat sarbecoviruses, finding that generalist ACE2 users are more related to SARS-CoV-2 and show broader cross-neutralization.
Jerry C H Tam, Abbie C. Sibayan, Jeffrey Seow…·Katie J. Doores
This study shows that Spike-specific IgG4 generated after BNT162b2 vaccination can inhibit effector functions when competing with other IgG subclasses, despite overall increased neutralization and effector activity.
Jeffrey Seow, George C.E. Jefferson, Michael D. Keegan…·Katie J. Doores
This study maps epitope immunodominance in sera following SARS-CoV-2 primary and breakthrough infections, revealing variant-specific epitope usage and immune imprinting effects.
Julia S. El-Sayed Moustafa, Anne Jackson, Sarah M. Brotman…·Kerrin S. Small
The paper examines the association between adipose tissue ACE2 expression and cardio-metabolic risk factors, finding lower ACE2 levels linked to T2D, obesity, and inflammation-related cell type changes.