Katie J. Doores

This study shows that Gag proteolysis drives HIV-1 Env conformational closure through the gp41 cytoplasmic tail, revealing a mechanism for immune evasion.

The paper maps glycan composition across HIV-1 pseudoviruses to show how sequence diversity affects the glycan shield and its vulnerability to broadly neutralizing antibodies.

The paper identifies diverse spike haplotypes in persistent SARS-CoV-2 infections that show immune escape mechanisms similar to variants of concern.

This study investigates the B-cell response to transient HIV viraemia in elite controllers, revealing TLM heterogeneity and the role of innate-like B cells.

This study identifies cross-neutralizing mAbs against diverse bat sarbecoviruses and characterizes their conserved epitopes for vaccine design.

This study examines the host range and antigenicity of bat sarbecoviruses, finding that generalist ACE2 users are more related to SARS-CoV-2 and show broader cross-neutralization.

This study shows that Spike-specific IgG4 generated after BNT162b2 vaccination can inhibit effector functions when competing with other IgG subclasses, despite overall increased neutralization and effector activity.

The paper determines the crystal structures of New World arenavirus GP1-GP2 complexes, revealing structural differences from Old World counterparts and demonstrating their antigenic relevance for vaccine development.

This study maps epitope immunodominance in sera following SARS-CoV-2 primary and breakthrough infections, revealing variant-specific epitope usage and immune imprinting effects.

The paper examines the association between adipose tissue ACE2 expression and cardio-metabolic risk factors, finding lower ACE2 levels linked to T2D, obesity, and inflammation-related cell type changes.