Hypoxia and epithelial to mesenchymal transition pathways are enriched in bladder tumor epithelium adjacent to tertiary lymphoid structures
Kartik Sachdeva, Priyanka Yolmo, Abdulhameed Abdulhamed, Gwenaëlle Conseil, Sadaf Rahimi, David Monty Berman, Kathrin Tyryshkin, Roger Li, D. Robert Siemens, Madhuri Koti
The paper examines TLS-adjacent tumor epithelium in bladder cancer, finding enrichment of hypoxia and EMT pathways linked to immune exhaustion and disease progression.
bioRxiv · Aug 11, 2026 · PreprintCancer Biology