Author

Mitchell A Jeffs

Queen's UniversityORCID 0000-0002-0809-5038Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Christopher T. LohansiD· 2 shared Josephine L Liu· 2 shared Abdulhameed Abdulhamed· 1 shared Alanna Brewer· 1 shared Amir HorowitziD· 1 shared Ashley Griffin· 1 shared Christophe GonçalvesiD· 1 shared D. Robert SiemensiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

Christopher T. LohansORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

B cell exhaustion associates with poor response to Bacillus Calmette-Guerin immunotherapy in patients with bladder cancer

Priyanka Yolmo, Kartik Sachdeva, Alanna Brewer, Sindhuja Pattabhi, Gwenaëlle Conseil, Abdulhameed Abdulhamed, Ashley Griffin, Mitchell A Jeffs, Haocheng Yu, David P. Cook, Roger Li, Sonia Victoria Del Rincon, Madelyn Jean Abraham, Christophe Gonçalves, Lars Dyrskjøt, , Madhuri Koti

The paper identifies atypical B cells (ABCs) as mediators of poor response to BCG immunotherapy in high-risk NMIBC patients, linking their expansion and FCRL5 expression to early recurrence.

bioRxiv · Jun 1, 2026 · PreprintCancer Biology

Rapid Detection of Carbapenemase-Producing Organisms Using a Luminescent Biosensor

Mitchell A Jeffs, Shreyas Bhat, Josephine L Liu, Rachel A. V. Gray, Xena X. Li, Prameet M. Sheth, Christopher T. Lohans

This paper introduces a luminescent biosensor for rapid detection of carbapenemase-producing organisms with 100% sensitivity and specificity.

ACS Infectious Diseases · Aug 8, 2025Peer-reviewedMicrobiology

Contributions of β-lactamase substrate specificity and outer membrane permeability to the antibiotic sheltering of β-lactam-susceptible bacteria

Montserrat Mora-Ochomogo, Mitchell A Jeffs, Josephine L Liu, Christopher T. Lohans

This study develops a luminescence assay to quantify antibiotic sheltering in mixed microbial populations and identifies factors influencing this phenomenon.

RSC Chemical Biology · Jan 1, 2025Peer-reviewedMicrobiology