Author

D. Robert Siemens

Queen's UniversityORCID 0000-0002-3203-6468Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Assay:proteomics· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1

Frequent Co-Authors

David Monty BermaniD· 3 shared Madhuri KotiiD· 3 shared Abdulhameed Abdulhamed· 2 shared Andrew W. CraigiD· 2 shared Charles H. GrahamiD· 2 shared Gwenaëlle ConseiliD· 2 shared Kartik SachdevaiD· 2 shared Peter A. GreeriD· 2 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCancer Biology

David Monty BermanORCID

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4 papers

Recent·Most cited

Differential effects of BCG-Russia and BCG-TICE on trained immunity: potential implications for bladder cancer immunotherapy

Richard W. Nauman, Peter A. Greer, Andrew W. Craig, Tiziana Cotechini, D. Robert Siemens, Charles H. Graham

This study compares the effects of BCG-Russia and BCG-TICE on trained immunity in mice, finding BCG-TICE induces stronger innate immune memory and inflammation-related gene expression.

PLoS ONE · Sep 11, 2026Peer-reviewedImmunology

Hypoxia and epithelial to mesenchymal transition pathways are enriched in bladder tumor epithelium adjacent to tertiary lymphoid structures

Kartik Sachdeva, Priyanka Yolmo, Abdulhameed Abdulhamed, Gwenaëlle Conseil, Sadaf Rahimi, David Monty Berman, Kathrin Tyryshkin, Roger Li, D. Robert Siemens, Madhuri Koti

The paper examines TLS-adjacent tumor epithelium in bladder cancer, finding enrichment of hypoxia and EMT pathways linked to immune exhaustion and disease progression.

bioRxiv · Aug 11, 2026 · PreprintCancer Biology

B cell exhaustion associates with poor response to Bacillus Calmette-Guerin immunotherapy in patients with bladder cancer

Priyanka Yolmo, Kartik Sachdeva, Alanna Brewer, Sindhuja Pattabhi, Gwenaëlle Conseil, Abdulhameed Abdulhamed, Ashley Griffin, Mitchell A Jeffs, Haocheng Yu, David P. Cook, Roger Li, Sonia Victoria Del Rincon, Madelyn Jean Abraham, Christophe Gonçalves, Lars Dyrskjøt, , Madhuri Koti

The paper identifies atypical B cells (ABCs) as mediators of poor response to BCG immunotherapy in high-risk NMIBC patients, linking their expansion and FCRL5 expression to early recurrence.

bioRxiv · Jun 1, 2026 · PreprintCancer Biology

Failure of Bacillus Calmette-Guerin Therapy in Patients with Bladder Cancer is Characterized by Immune Dysfunction Associated with Activator Protein 1

Andrew Garven, Jean‐François Paré, Alexandra Robins, Ana Vera-Rodríguez, Rohan Sampy, Arianna Bennett, Richard W. Nauman, Andrew W. Craig, Peter A. Greer, Madhuri Koti, Tiziana Cotechini, David Monty Berman, Amber Simpson, Lynne-Marie M Postovit, D. Robert Siemens, Charles H. Graham

This study identifies immune dysfunction linked to AP-1 in BCG non-responders with NMIBC, suggesting pre-existing immunosenescence contributes to early recurrence.

bioRxiv · May 10, 2026 · PreprintCancer Biology