B cell exhaustion associates with poor response to Bacillus Calmette-Guerin immunotherapy in patients with bladder cancer
Priyanka Yolmo, Kartik Sachdeva, Alanna Brewer, Sindhuja Pattabhi, Gwenaëlle Conseil, Abdulhameed Abdulhamed, Ashley Griffin, Mitchell A Jeffs, Haocheng Yu, David P. Cook, Roger Li, Sonia Victoria Del Rincon, Madelyn Jean Abraham, Christophe Gonçalves, Lars Dyrskjøt, , Madhuri Koti
The paper identifies atypical B cells (ABCs) as mediators of poor response to BCG immunotherapy in high-risk NMIBC patients, linking their expansion and FCRL5 expression to early recurrence.
bioRxiv · Jun 1, 2026 · PreprintCancer Biology