Mapping kinase-dependent tumor immune adaptation with multiplexed single-cell CRISPR screens
Lingting Shi, Ross M. Giglio, Qingyuan Cai, Mathini Vaikunthan, Justin Hong, Abdullah Naqvi, Marina Milea, Hannah Khanshali, Anna Schoonen, Nicholas Y. Hou, Jonathan Guo, Melanie Fraidenburg, Xumin Shen, Seth W. Malinowski, Keith Lloyd Ligon, , José L. McFaline‐Figueroa
The paper develops a CRISPR screening framework to map kinase-dependent immune evasion mechanisms in glioblastoma by integrating single-cell transcriptomics and deep generative models.
bioRxiv · Feb 28, 2026 · PreprintGenomics