Author

Nicholas Y. Hou

Columbia University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Developmental Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:benchmarking· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

José L. McFaline‐FigueroaiD· 3 shared Elham AziziiD· 2 shared Justin HongiD· 2 shared Keith Lloyd LigoniD· 2 shared Lingting ShiiD· 2 shared Mathini VaikunthaniD· 2 shared Ross M. GiglioiD· 2 shared Seth W. MalinowskiiD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersGenomics

José L. McFaline‐FigueroaORCID

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Author profile →

4 papers

Recent·Most cited

Mapping kinase-dependent tumor immune adaptation with multiplexed single-cell CRISPR screens

Lingting Shi, Ross M. Giglio, Qingyuan Cai, Mathini Vaikunthan, Justin Hong, Abdullah Naqvi, Marina Milea, Hannah Khanshali, Anna Schoonen, Nicholas Y. Hou, Jonathan Guo, Melanie Fraidenburg, Xumin Shen, Seth W. Malinowski, Keith Lloyd Ligon, , José L. McFaline‐Figueroa

The paper develops a CRISPR screening framework to map kinase-dependent immune evasion mechanisms in glioblastoma by integrating single-cell transcriptomics and deep generative models.

bioRxiv · Feb 28, 2026 · PreprintGenomics

A robust human airway organoid platform enables scalable expansion and trajectory mapping of pulmonary neuroendocrine cells

Noah Candeli, Lisanne den Hartigh, Nicholas Y. Hou, Andrés Marco Giménez, Jose Antonio Sanchez-Villacana, Andrea García González, Shashank Gandhi, Francesca Sgualdino, Alyssa J. Miller, J R Spence, Susana Chuva de Sousa Lopes, José L. McFaline‐Figueroa, Hans C. Clevers, Talya L. Dayton

This paper develops a human airway organoid platform to expand and map the differentiation trajectories of pulmonary neuroendocrine cells.

bioRxiv · Feb 3, 2026 · PreprintDevelopmental Biology

A heterogeneous pharmaco-transcriptomic landscape induced by targeting a single oncogenic kinase

Ross M. Giglio, Nicholas Y. Hou, Lingting Shi, Adeya Wyatt, Justin Hong, Mathini Vaikunthan, Charlotte Bellamy, Henry Fuchs, Vivian Lu, Ndubuisi Obasi, Jose Pomarino Nima, Seth W. Malinowski, Keith Lloyd Ligon, José L. McFaline‐Figueroa, Nir Yosef, , Jose Ricardo McFaline-Figueroa

This study uses SCHEMATIC to analyze the molecular response of glioblastoma to EGFR inhibitors, identifying chemotype-specific programs and showing that combined EGFR/PI3K inhibition reduces adaptive transcription.

bioRxiv · Apr 8, 2024 · PreprintGenomics

A programmable probiotic encapsulation system enhances therapeutic delivery in vivo

Tetsuhiro Harimoto, Jaeseung Hahn, Yuyu Chen, Jongwon Im, Joanna T. Zhang, Nicholas Y. Hou, Fangda Li, Courtney Coker, Kelsey Gray, Nicole Harr, Sreyan Chowdhury, Kelly Pu, Clare A. Nimura, Nicholas Arpaia, Kam W. Leong, Tal Danino

This paper develops a programmable probiotic encapsulation system using synthetic biology to enhance therapeutic delivery in mice by controlling bacterial immunogenicity and survivability.

bioRxiv · Aug 3, 2021 · PreprintSynthetic Biology