Author

Melanie Fraidenburg

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Isaac Yi KimiD· 2 shared Longjun Li· 2 shared Ping MuiD· 2 shared Siyuan ChengiD· 2 shared Yuyin JiangiD· 2 shared Abdullah Naqvi· 1 shared Anna Schoonen· 1 shared Catherine Yijia Zhang· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

Isaac Yi KimORCID

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Author profile →

3 papers

Recent·Most cited

Mapping kinase-dependent tumor immune adaptation with multiplexed single-cell CRISPR screens

Lingting Shi, Ross M. Giglio, Qingyuan Cai, Mathini Vaikunthan, Justin Hong, Abdullah Naqvi, Marina Milea, Hannah Khanshali, Anna Schoonen, Nicholas Y. Hou, Jonathan Guo, Melanie Fraidenburg, Xumin Shen, Seth W. Malinowski, Keith Lloyd Ligon, , José L. McFaline‐Figueroa

The paper develops a CRISPR screening framework to map kinase-dependent immune evasion mechanisms in glioblastoma by integrating single-cell transcriptomics and deep generative models.

bioRxiv · Feb 28, 2026 · PreprintGenomics

Graded Notch Signaling Functions as a Rheostat of Lineage Plasticity and Therapy Resistance in Prostate Cancer

Yuyin Jiang, Siyuan Cheng, Catherine Yijia Zhang, Xiao Jin, Longjun Li, Melanie Fraidenburg, Choushi Wang, Isaac Yi Kim, Ping Mu

This study identifies Notch signaling as a graded rheostat regulating lineage plasticity and therapy resistance in prostate cancer, showing that intermediate Notch activity maintains stem-like progenitor states and that modulating Notch levels can restore drug sensitivity.

bioRxiv · Nov 23, 2025 · PreprintCancer Biology

Notch as a Driver of Lineage Plasticity and Therapeutic Target in Enzalutamide-Resistant Prostate Cancer

Yuyin Jiang, Siyuan Cheng, Longjun Li, Melanie Fraidenburg, Isaac Yi Kim, Su Deng, Ping Mu

This study identifies Notch signaling as a driver of lineage plasticity and therapeutic resistance in enzalutamide-resistant prostate cancer and shows its inhibition reverses resistance in vitro.

bioRxiv · May 26, 2025 · PreprintCancer Biology