Tamoxifen and Doxorubicin Synergistically Target Estrogen Receptor beta-Mutant p53-p73 Axis, a Therapeutically Actionable Vulnerability in Triple Negative Breast Cancer
Chetan C. Oturkar, Junhoung Park J, Iqbal Ijaz, Christina Adams, Utpal Kumar Mukhopadhyay, Melissa Dolan, Alexander Caradori, Manasori Oshi, Yali Zhang, J. Wang, Brent Boleslav, Donald E. Mager, Abhlash Nair, Tagari Samanta, Kwang Hwa Jung, , Gokul M. Das
This paper shows that Tamoxifen and Doxorubicin together target the ER beta-mutant p53-p73 axis in TNBC, enhancing cell death through apoptosis and ferroptosis.
bioRxiv · Oct 23, 2026 · PreprintCancer Biology