Control of MYC-dependent apoptotic threshold by a co-amplified ubiquitin E3 ligase UBR5
Xi Qiao, Ying Liu, Maria Llamazares Prada, Abhishekh Gupta, Alok Jaiswal, Mukund Sharma, Heidi Haikala, Kati Talvinen, Laxman Yetukuri, Joanna W. Pylvänäinen, Juha Klefström, Pauliina Kronqvist, Annika Meinander, Tero Aittokallio, Ville Hietakangas, , Jukka Westermarck
This study identifies UBR5 as a novel MYC ubiquitin ligase that regulates MYC protein stability and apoptotic threshold in cancer cells and breast tissue.
bioRxiv · Jan 8, 2019 · PreprintCancer Biology