Designer small molecule control system based on Minocycline induced disruption of protein-protein interaction.
Ram Jha, Alexander Kinna, Alastair Hotblack, Reyisa Bughda, Anna M. Bulek, Isaac Gannon, F. Tudor Ilca, Christopher G. Allen, Katarina Lamb, Abigail Dolor, Ian Scott, Farhaan Parekh, James Sillibourne, Shaun P Cordoba, Shimobi C. Onuoha, , Martin A. Pulè
The paper develops a small-molecule control system using minocycline to disrupt protein-protein interactions for reversible and dose-dependent control of therapeutic applications.
ACS Chemical Biology · Jan 20, 2024Peer-reviewedMolecular Biology