C. elegans small heat-shock protein HSP-12.6 has a highly specialized protective function towards muscle thick filaments in vivo
Abigail Fern, Jasmine Alexander-Floyd, Anhelina Volchok, Susan M. Cahill, Srikar Donepudi, Jana Smuts, Tali Gidalevitz
This study identifies HSP-12.6 as a specialized chaperone protecting muscle thick filaments in C. elegans, showing selectivity for myosin-containing structures over other muscle components.
bioRxiv · May 20, 2026 · PreprintCell Biology