Tali Gidalevitz

C. elegans small heat-shock protein HSP-12.6 has a highly specialized protective function towards muscle thick filaments in vivo

This study identifies HSP-12.6 as a specialized chaperone protecting muscle thick filaments in C. elegans, showing selectivity for myosin-containing structures over other muscle components.

IGF-like growth factors that couple food sensing to developmental decisions employ different release mechanisms in a single pair of C. elegans chemosensory neurons

This study identifies divergent molecular pathways for the axonal localization and release of neuropeptides and IGF-like growth factors in C. elegans chemosensory neurons.

Increased activity of IRE1 improves the clinical presentation of EAE

This study shows that increased IRE1 activity in a mouse model of EAE reduces inflammation and improves motor function, suggesting context-dependent protective effects of ER stress.

Natural variants in C. elegans atg-5 3’UTR uncover divergent effects of autophagy on polyglutamine aggregation in different tissues

The paper identifies a genetic variant in C. elegans atg-5 that alters autophagy's effect on polyglutamine aggregation, showing tissue-dependent outcomes.