SCD1 and SCD5 Modulate PARP-Dependent DNA Repair via Fatty Acid Desaturation in Glioblastoma
Hayk Mnatsakanyan, Alessandro Sammarco, Abigail Hewett, Rami Awwad, Elie Roumieh, Caline Pechdimaljian, Çağrı Çakici, Caroline M. Spangler, Yana Azar, Richa Pradhan, Baolong Su, Kevin J. Williams, Steven J. Bensinger, Christian E. Badr
This study shows SCD1 and SCD5 modulate DNA repair in glioblastoma via fatty acid desaturation, with SCD5 specifically affecting sphingolipids and PARP1 activity.
Cell Reports · Apr 1, 2026Peer-reviewedCancer Biology