Author

Alessandro Sammarco

University of California, Los AngelesORCID 0000-0003-1977-3292Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Steven J. BensingeriD· 3 shared Baolong SuiD· 2 shared Çağrı ÇakiciiD· 2 shared Christian E. BadriD· 2 shared Hayk MnatsakanyaniD· 2 shared Kevin J. WilliamsiD· 2 shared Abigail Hewett· 1 shared Ajit S. DivakaruniiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

Steven J. BensingerORCID

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3 papers

Recent·Most cited

ImmunologyEMBO ReportsPeer-reviewedSep 18, 2026

The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling

Anthony E. Jones, Amy Rios, Neira Ibrahimovic…·Ajit S. Divakaruni

This study shows Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling by providing a weak TLR4 signal.

4 citations

mousebulk RNA-seq

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Cancer BiologyCell ReportsPeer-reviewedApr 1, 2026

SCD1 and SCD5 Modulate PARP-Dependent DNA Repair via Fatty Acid Desaturation in Glioblastoma

Hayk Mnatsakanyan, Alessandro Sammarco, Abigail Hewett…·Christian E. Badr

This study shows SCD1 and SCD5 modulate DNA repair in glioblastoma via fatty acid desaturation, with SCD5 specifically affecting sphingolipids and PARP1 activity.

10 citationstop 1%

humanproteomics

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Cancer BiologyCommunications BiologyPeer-reviewedApr 4, 2025

Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast cancer brain metastasis mouse models

Alessandro Sammarco, Giorgia Guerra, Katharina M. Eyme…·Christian E. Badr

This study shows that inhibiting SCD in breast cancer brain metastases induces lipotoxicity and enhances anti-tumor immunity, improving survival in mouse models.

11 citations

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