Hayk Mnatsakanyan

The paper introduces SCIENCE-seq, a single-cell interactomics platform that maps RNA-RNA and DNA-DNA interactions in cancer, identifying therapeutic targets through chromatin architectures.

This study shows SCD1 and SCD5 modulate DNA repair in glioblastoma via fatty acid desaturation, with SCD5 specifically affecting sphingolipids and PARP1 activity.

This study shows NaBC1 enhances myoblast adhesion and polarization by interacting with fibronectin-binding integrins and modulating mechanotransduction.

This study shows that inhibiting SCD in breast cancer brain metastases induces lipotoxicity and enhances anti-tumor immunity, improving survival in mouse models.

This paper introduces Multi-Region Brain Organoids (MRBOs) that integrate cerebral, mid/hindbrain, and complex endothelial components, revealing new roles for endothelial cells in brain development.