Kevin J. Williams

This study identifies SCD as a lipid metabolic checkpoint that regulates macrophage activation and plasticity by maintaining lipid desaturation balance and preventing pro-inflammatory responses.

This study shows SCD1 and SCD5 modulate DNA repair in glioblastoma via fatty acid desaturation, with SCD5 specifically affecting sphingolipids and PARP1 activity.

This study shows that PPARγ controls adipose tissue expansion by regulating LPCAT3, which affects membrane lipid composition and triglyceride storage, linking dietary n-6 PUFAs to energy balance.

This study shows that dietary lipids, not ketone body metabolites, drive intestinal tumorigenesis in ketogenic diets, highlighting the role of fatty acid oxidation.

The paper identifies LPCAT3 as a cold-regulated enzyme that generates AA-PE in BAT mitochondria, enhancing ETC efficiency and thermogenesis.

The paper shows c-Rel, an NF-κB family member, evolved unique DNA-binding properties in mammals, enhancing its ability to regulate Il12b and support immune complexity.

This study shows that inhibiting SCD in breast cancer brain metastases induces lipotoxicity and enhances anti-tumor immunity, improving survival in mouse models.

This study identifies metabolic defects in PKP2-deficient cardiomyocytes and shows that restoring PKP2 improves contractility and electrophysiological properties.

This study examines how different blood flow patterns alter the lipidome of human aortic endothelial cells and identifies stimulus-specific lipid reprogramming in response to pro-inflammatory agonists.

This study shows IL-4 promotes B cell activation by upregulating cholesterol synthesis, which is essential for ER expansion, cell cycle progression, and proliferation during influenza infection.