Discovery of a Novel High-Salt-Adapted Archaeal AP Endonuclease using Microfluidics-Based Cell-Free Functional Metagenomics
Joan Castells-Ballester, Abigail Taron, Amit Sinha, Madison Boisvert, Madison Smith, Minyong Chen
The paper discovers a novel archaeal AP endonuclease from a salt marsh metagenome using cell-free functional metagenomics, showing its high salt tolerance and structural similarity to human APE1.
bioRxiv · Oct 17, 2026 · PreprintSynthetic Biology