Minyong Chen

The paper discovers a novel archaeal AP endonuclease from a salt marsh metagenome using cell-free functional metagenomics, showing its high salt tolerance and structural similarity to human APE1.

The paper develops a microdroplet-based functional genomic screening pipeline using DNA nanoflowers and cell-free expression to identify DNA-interacting enzymes.

The paper introduces a high-resolution single-molecule chromatin accessibility mapping method to quantify transcription factor occupancy and co-accessibility in human cell lines.

The paper discovers novel DNA cytosine deaminases and develops a nondestructive single-enzyme methylation sequencing method for high-coverage methylome mapping of low-input DNA.

The paper identifies two distinct error profiles in FFPE DNA caused by cytosine and methylcytosine deamination and shows how specific repair strategies can mitigate these errors.