Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing
Han Chen, Constantin Cretu, Abigail Trebilcock, Natalia Evdokimova, Norbert Zsolt Babai, Laura Feldmann, Florian Leidner, Fritz Benseler, Sophia Mutschall, Klara Esch, Csaba Zoltán Kibédi Szabó, Vladimir Peña, Constantin Pape, Helmut Grubmüller, Nicola Strenzke, , Tobias Moser
The paper investigates the structure and function of otoferlin, showing how it binds Ca2+ and facilitates synaptic vesicle fusion in inner hair cells.
Science Advances · Oct 15, 2025Peer-reviewedNeuroscience