Carolin Wichmann

The paper investigates the structure and function of otoferlin, showing how it binds Ca2+ and facilitates synaptic vesicle fusion in inner hair cells.

SynapseNet automatically segments synapses in electron micrographs using deep learning, enabling efficient analysis of synaptic structures.

This study identifies Paralemmin-3 as a critical protein for maintaining the structural integrity of the lateral wall in auditory hair cells, with its loss causing hearing impairment and structural collapse.

This study shows that variations in Ca2+ channel activation in inner hair cells affect spiral ganglion neuron firing rates and sound threshold, with implications for noise-induced hearing loss in patients with the CaV1.3A749G mutation.

The paper investigates neuromodulation of the endbulb of Held synapse in the cochlear nucleus, finding that norepinephrine increases miniature excitatory postsynaptic currents while serotonin and evoked transmission are unaffected.

This study uses optogenetics and electron tomography to analyze the ultrastructure of cochlear inner hair cell ribbon synapses during stimulation, showing increased docked synaptic vesicles and no evidence of homotypic fusion.

This study investigates the role of piccolino in cochlear inner hair cell synapses, finding it contributes to active zone organization and is essential for normal synaptic transmission.

This paper investigates the role of RIM-BP2 in organizing Ca2+ channel topography and regulating synaptic vesicle release probability and replenishment at a fast central synapse.

The paper shows that 30% of inner hair cells in the rodent cochlea form electrochemical mini-syncytia through membrane fusion, enhancing sound encoding sensitivity and reliability.