Author

Florian Leidner

Max Planck Institute for Multidisciplinary SciencesORCID 0000-0002-0048-889XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Helmut GrubmülleriD· 2 shared Abigail Trebilcock· 1 shared Aikaterini VrentzouiD· 1 shared Akbar AliiD· 1 shared Alexander SteiniD· 1 shared Carolin WichmanniD· 1 shared Celia A. SchifferiD· 1 shared Claudia C. SchmidtiD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersNeuroscience

Helmut GrubmüllerORCID

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3 papers

Recent·Most cited

Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing

Han Chen, Constantin Cretu, Abigail Trebilcock, Natalia Evdokimova, Norbert Zsolt Babai, Laura Feldmann, Florian Leidner, Fritz Benseler, Sophia Mutschall, Klara Esch, Csaba Zoltán Kibédi Szabó, Vladimir Peña, Constantin Pape, Helmut Grubmüller, Nicola Strenzke, , Tobias Moser

The paper investigates the structure and function of otoferlin, showing how it binds Ca2+ and facilitates synaptic vesicle fusion in inner hair cells.

Science Advances · Oct 15, 2025Peer-reviewedNeuroscience

UBE2J2 sensitizes the ERAD ubiquitination cascade to changes in membrane lipid saturation

Aikaterini Vrentzou, Florian Leidner, Claudia C. Schmidt, Helmut Grubmüller, Alexander Stein

The paper shows UBE2J2 senses membrane lipid saturation by modulating its activity and interaction with E3 ligases, affecting ERAD ubiquitination.

Nature Communications · Oct 9, 2025Peer-reviewedBiochemistry

Structural Adaptation of Darunavir Analogs Against Primary Resistance Mutations in HIV-1 Protease

G.J. Lockbaum, Florian Leidner, Linah N. Rusere, M. Henes, K. Kosovrasti, Gily S. Nachum, E.A. Nalivaika, Akbar Ali, Neşe Kurt Yılmaz, Celia A. Schiffer

The paper investigates how structural changes in HIV-1 protease affect the potency of Darunavir and its analogs against primary resistance mutations using crystal structures and vdW interaction analysis.

ACS Infectious Diseases · Dec 13, 2018Peer-reviewedMolecular Biology