Author

Klara Esch

Universitätsmedizin GöttingenORCID 0000-0002-0729-4713Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:imaging· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Tobias MoseriD· 2 shared Abigail Trebilcock· 1 shared Carolin WichmanniD· 1 shared Constantin CretuiD· 1 shared Constantin PapeiD· 1 shared Csaba Zoltán Kibédi Szabó· 1 shared Evelyn GarlickiD· 1 shared Florian LeidneriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Tobias MoserORCID

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2 papers

Recent·Most cited

Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy

Rohan Kapoor, Hyojin Kim, Evelyn Garlick, Maria Augusta do Rego Barros Fernandes Lima, Klara Esch, Torben Ruhwedel, Wiebke Möbius, Fred Wolf, Tobias Moser

This study uses MINFLUX nanoscopy to map the nanoscale organization of proteins at inner hair cell synapses in mice, revealing nanocluster-based structures in active zones and postsynaptic densities.

Science Advances · Nov 5, 2025Peer-reviewedNeuroscience

Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing

Han Chen, Constantin Cretu, Abigail Trebilcock, Natalia Evdokimova, Norbert Zsolt Babai, Laura Feldmann, Florian Leidner, Fritz Benseler, Sophia Mutschall, Klara Esch, Csaba Zoltán Kibédi Szabó, Vladimir Peña, Constantin Pape, Helmut Grubmüller, Nicola Strenzke, , Tobias Moser

The paper investigates the structure and function of otoferlin, showing how it binds Ca2+ and facilitates synaptic vesicle fusion in inner hair cells.

Science Advances · Oct 15, 2025Peer-reviewedNeuroscience