Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress
Rosanna J. Wilkins, Abirami Kannan, Siobhan Plass, Claire Wilson, Richard D. Kelly, Claire H. M. Tang, Panagiotis Kotsantis, Martin A.M. Reijns, Aditi Kanhere, Eva Petermann
This study shows that RNase H2 upregulation mitigates replication stress caused by oncogenes and chemotherapy, reducing replication fork stalling and RNA:DNA hybrids.
Oncogene · Jul 10, 2025Peer-reviewedMolecular Biology