Richard D. Kelly

This study shows that 7SK-snRNP components HEXIM1 and LARP7 promote replication fork reversal and homologous recombination under transcription and replication stress, independent of BRCA1.

This study shows that PI3K-AKT activation is required for RAS-induced replication stress and hypertranscription in cancer cells.

This study shows that RNase H2 upregulation mitigates replication stress caused by oncogenes and chemotherapy, reducing replication fork stalling and RNA:DNA hybrids.

This study shows that KDM5's non-enzymatic activities, not just demethylation, are critical for proper genomic organization and neuronal function in the brain.

This study examines how menopause and high fat diet affect metabolic outcomes in a mouse model of Alzheimer's disease, finding metabolic impairment and synergistic effects on biomarkers.

This study shows that menopause worsens metabolic issues in mice on a high-fat diet, with greater effects in middle-aged mice.

The paper shows HDACs maintain pluripotency by regulating RNA polymerase II recruitment to enhancer regions through histone acetylation and BRD4 interactions.

This study shows that brain-specific estrogen delivery via DHED improves spatial and working memory in post-menopausal mice.

This study shows that a high fat diet worsens cognitive decline and neuropathology in female mouse models of Alzheimer's and mixed dementia more than in males.

This study shows that PrimPol creates single-stranded gaps at bulky DNA adducts, which recruit RAD51 for homologous recombination, facilitating DNA repair in mammalian cells.