Rosanna J. Wilkins

This study shows that 7SK-snRNP components HEXIM1 and LARP7 promote replication fork reversal and homologous recombination under transcription and replication stress, independent of BRCA1.

This study shows that PI3K-AKT activation is required for RAS-induced replication stress and hypertranscription in cancer cells.

This study shows that RNase H2 upregulation mitigates replication stress caused by oncogenes and chemotherapy, reducing replication fork stalling and RNA:DNA hybrids.