Mesenchymal WNT2B is Required for the Development and Function of the Human Intestine
Akaljot Singh, Holly M. Poling, Jennifer D. Foulke-Abel, Nambirajan Sundaram, Abid A. Reza, Sarah Joseph, Abrahim ElSeht, Kalpana Srivasta, Maksym Krutko, Christopher N. Mayhew, David T. Breault, James M. Wells, Jay R. Thiagarajah, Amy E. O’Connell, Olga N. Kovbasnjuk, Michael A. Helmrath
This study identifies mesenchymal WNT2B as critical for human intestinal epithelial development and function using patient-derived organoids and transcriptomic analysis.
bioRxiv · May 1, 2025 · PreprintDevelopmental Biology