David T. Breault

This study identifies EGFR inhibitors as inducers of enteroendocrine cell differentiation, linking their use to treatment-associated diarrhea through STAT1 signaling activation.

This study shows that early-life mucosal T cells promote intestinal stem cell renewal and secretory differentiation through direct interactions and signaling, with impaired function in NEC and adult T cells.

This study identifies Blautia wexlerae's role in converting dietary fats into bioactive metabolites that enhance gut hormone secretion and improve metabolic health in mice and humans.

This study shows that β-Catenin-driven hyperplasia in the adrenal cortex is mediated through Rho-ROCK signaling and Cat-dependent stabilization of adherens junctions.

This study identifies glutamine antagonism as a therapeutic strategy for adrenocortical carcinoma by inhibiting de novo nucleotide biosynthesis and inducing DNA damage.

This study shows that loss of WNT2B promotes colorectal cancer progression in mouse models and is associated with poor patient survival in human samples.

This study identifies mesenchymal WNT2B as critical for human intestinal epithelial development and function using patient-derived organoids and transcriptomic analysis.

This paper identifies DLK1 as a marker of adrenocortical stem/progenitor cells that predicts malignancy in adrenocortical carcinoma and is detectable in patient serum.

The paper shows that colitis leaves an epigenetic memory in colonic stem cells that promotes tumor growth by enhancing regenerative gene programs and AP-1 activity.

This paper introduces a human mesofluidic intestinal chip to study transport of drug carriers and bacteria through a live mucosal barrier, revealing mucus dynamics and particle interactions.

The paper uses bulk RNA-Seq to analyze gene expression changes in mouse duodenum and ileum during the first postnatal month, identifying key molecular shifts and comparing them to human data.

This study identifies WNT2B as a key regulator of adrenal aldosterone production, showing its role in zG function and linking its variants to primary aldosteronism and a new form of familial hypoaldosteronism.

This study shows WNT2B deficiency in mice increases colitis susceptibility and impairs human intestinal development, with distinct effects in small intestine and colon.

This study identifies TERT-expressing cells as a novel multipotent stem cell population in the adult mouse brain, capable of differentiating into multiple cell types.

This study develops a method to differentiate human intestinal stem cells into functional enteroendocrine cells using small molecule targeting of specific signaling pathways.

The paper shows that mutations in PKAc cause displacement from AKAP signaling islands, leading to distinct pathogenic signaling pathways in Cushing's syndrome.