Nambirajan Sundaram

This study identifies mesenchymal WNT2B as critical for human intestinal epithelial development and function using patient-derived organoids and transcriptomic analysis.

This paper describes a method to integrate collecting systems in kidney organoids by fusing distal nephron with ureteric bud tissues, enabling functional nephrons with continuous epithelial lumens.

This study develops a human pluripotent stem cell-derived organoid system to investigate vascular, mesenchymal, and epithelial co-development in lung and intestinal organoids, revealing organ-specific endothelial and mesenchymal features.

The paper develops a method to engineer functional human gastrointestinal organoids by assembling cells from the three primary germ layers, revealing the role of the enteric nervous system in tissue development.

This study investigates circadian rhythms in human intestinal organoids, showing circadian phase-dependent necrotic cell death responses to TcdB and identifying anti-phasic gene expression between mouse and human enteroids.

This study shows that non-adhesive alginate hydrogels support the growth and differentiation of human intestinal organoids, comparable to Matrigel.