Michael A. Helmrath

This study shows that piezoelectric nanofiber scaffolds promote faster spheroid formation and support intestinal organoid development without adverse effects.

This study investigates how organ-specific extracellular vesicles (sEVs) contribute to metabolic improvements after vertical sleeve gastrectomy (VSG) in adolescents with obesity, finding that liver-derived sEVs correlate with BMI and BCAAs, while adipose-derived sEVs correlate with liver function markers.

This study enhances the piezoelectric properties of PVDF-TrFE nanofibers through annealing, showing improved mechanical and biological responses for tissue engineering.

This paper introduces a confined culture system to generate innervated human gut organoids that mature faster and support transplantation, enhancing engraftment and function.

This study identifies mesenchymal WNT2B as critical for human intestinal epithelial development and function using patient-derived organoids and transcriptomic analysis.

This paper describes a method to integrate collecting systems in kidney organoids by fusing distal nephron with ureteric bud tissues, enabling functional nephrons with continuous epithelial lumens.

The paper tests eicosatetraynoic acid (ETYA) in a human intestinal organoid model to suppress pro-fibrotic pathways in macrophages associated with Crohn's Disease.

This study develops a human pluripotent stem cell-derived organoid system to investigate vascular, mesenchymal, and epithelial co-development in lung and intestinal organoids, revealing organ-specific endothelial and mesenchymal features.

This study shows WNT2B deficiency in mice increases colitis susceptibility and impairs human intestinal development, with distinct effects in small intestine and colon.

The paper develops a method to engineer functional human gastrointestinal organoids by assembling cells from the three primary germ layers, revealing the role of the enteric nervous system in tissue development.

This study investigates circadian rhythms in human intestinal organoids, showing circadian phase-dependent necrotic cell death responses to TcdB and identifying anti-phasic gene expression between mouse and human enteroids.

This study identifies major sources of transcriptomic variation in human intestinal organoids, showing that culture methods like substrate and format have large effects compared to experimental manipulations.

This study shows that non-adhesive alginate hydrogels support the growth and differentiation of human intestinal organoids, comparable to Matrigel.