Cancer BiologybioRxivPreprint
PAQR5 Membrane Progesterone Receptor Regulates the Blood-Brain Barrier during Brain Metastasis Formation
Csilla Fazakas, Attila G. Végh, Tamás Dudás…·Imola Wilhelm
This study identifies a mechanism by which triple-negative breast cancer-derived extracellular vesicles disrupt the blood-brain barrier by downregulating PAQR5/mPRγ, leading to increased cancer cell migration into the brain.