PAQR5 Membrane Progesterone Receptor Regulates the Blood-Brain Barrier during Brain Metastasis Formation
Csilla Fazakas, Attila G. Végh, Tamás Dudás, Dorina Varga, Adél Lüvi, Mónika Krecsmarik, András Dér, Attila E. Farkas, István Adorján Krizbai, Imola Wilhelm
This study identifies a mechanism by which triple-negative breast cancer-derived extracellular vesicles disrupt the blood-brain barrier by downregulating PAQR5/mPRγ, leading to increased cancer cell migration into the brain.
bioRxiv · Mar 18, 2026 · PreprintCancer Biology