Multiplexed CRISPR/Cas9 Editing of Tumor Suppressor Genes Recapitulates Molecular and Morphological Features of High-Risk Endometrial Cancer
Maria Vidal-Sabanés, Raúl Navaridas, Núria Bonifaci, Ada Gay-Rua, Damià Ortega-Peinado, Joaquim Egea, Mario Encinas, Xavier Matías‐Guiu, David Llobet-Navas, Xavier Dolcet
This study uses multiplexed CRISPR/Cas9 to edit multiple tumor suppressor genes in mouse endometrium, creating models of high-risk endometrial cancers with molecular and histological features similar to human tumors.
bioRxiv · Nov 28, 2025 · PreprintCancer Biology