Joaquim Egea

This study identifies FLRT3-RND3 signaling as a conserved negative regulator of cortical neuron migration and folding in mice.

This study shows that loss of miR-424(322)~503 worsens colon cancer in PTEN-deficient mice by activating MAPK and TGFβ pathways.

This study uses multiplexed CRISPR/Cas9 to edit multiple tumor suppressor genes in mouse endometrium, creating models of high-risk endometrial cancers with molecular and histological features similar to human tumors.

This study shows that miR-424(322)~503 cluster promotes endometrial cancer progression driven by PTEN deficiency by enhancing proliferation and blocking TGFβ-mediated apoptosis.

This study identifies a cytoplasmic function of cyclin D1 in radial glial progenitor cells that regulates cortical layering independent of cell cycle regulation.

The paper shows that non-apical mitoses in the mouse gastrulation streak, driven by actomyosin relaxation and accelerated cell cycles, contribute to cell delamination, but not mesoderm identity.

This study investigates adult-onset Sprouty1/2/4 triple knockout mice, revealing endocrine defects without increased tumor incidence.

This study identifies Ccnd1-Cdk4 as a regulator of GABAAR activity through phosphorylation, affecting neuronal signaling and synaptic pruning in mice.