Xavier Matías‐Guiu

This study shows that loss of miR-424(322)~503 worsens colon cancer in PTEN-deficient mice by activating MAPK and TGFβ pathways.

This study uses multiplexed CRISPR/Cas9 to edit multiple tumor suppressor genes in mouse endometrium, creating models of high-risk endometrial cancers with molecular and histological features similar to human tumors.

This study shows that miR-424(322)~503 cluster promotes endometrial cancer progression driven by PTEN deficiency by enhancing proliferation and blocking TGFβ-mediated apoptosis.

This study shows that cold ischemia time significantly affects molecular profiles in tumor and normal tissues, impacting drug target discovery.

This study investigates adult-onset Sprouty1/2/4 triple knockout mice, revealing endocrine defects without increased tumor incidence.