Aberrant Transitional Alveolar Epithelial Cells Promote Pathogenic Activation of Lung Fibroblasts in Preclinical Fibrosis Modeling
Evan T. Hoffman, Willy Roque Barboza, Luis R Rodriguez, Rachna Dherwani, Yaniv Tomer, Aditi Murthy, Adam Bennett, Ana N. Nottingham, Apoorva Babu, Katrina Chavez, Charlotte H Cooper, Maria Ciocca Basil, Micha Sam Brickman Raredon, Jeremy B. Katzen
This study identifies aberrant transitional alveolar epithelial cells in a mouse fibrosis model and shows they activate fibroblasts through a profibrotic secretome.
bioRxiv · Jun 17, 2024 · PreprintCell Biology